Contraindications : התוויות נגד

4.3    Contraindications
•   Hypersensitivity to the active substance, other β-blockers or to any of the excipients listed in section 6.1
•   Asthma or history of bronchospasm
•   Atrioventricular block of second or third degree
•   Uncontrolled heart failure
•   Clinically relevant sinus bradycardia (< 45-50 bpm)
•   Pri z etal’s angina
•   Sick-sinus syndrome (unless a pacemaker is in situ)
•   Severe peripheral arterial disease
•   Hypotension
•   Untreated phaeochromocytoma
•   Metabolic acidosis.
•   Myocardial infarction complicated by significant bradycardia, first degree heart block, systolic hypotension (less than 100mmHg) and/or severe heart failure and cardiogenic shock
•   Diabetes if associated with frequent episodes of hypoglycaemia •   Chronic obstructive pulmonary disease
•   Renal or hepatic failureTherapy resistant hypokalaemia and hyponatraemia, hypercalcaemia, symptomatic hyperuricaemia,
anuria.
•   The concomitant intravenous administration of calcium blockers of the type verapamil and diltiazem other antiarrhythmics (such as disopyramide) is contraindicated (exception: intensive care unit).