Pharmaceutical particulars : מידע רוקחי

6.    PHARMACEUTICAL PARTICULARS

6.1    List of excipients
Sodium edetate, sodium hydroxide, water for injections

6.2    Incompatibilities

Mesna is incompatible in vitro with carboplatin, cisplatin and nitrogen mustard. However, concomitant administration is possible if separate injection sites are used. These medications do not interact within the body.

Mixing mesna and epirubicin leads to inactivation of epirubicin and should be avoided.

6.3    Shelf life

The expiry date of the product is indicated on the packaging materials.

6.4 Special precautions for storage

Store below 30˚C
After reconstitution :
From a microbial point of view: use immediately
From a chemical point of view: 24 hours stored at 25 °C
Compatible with:
•     0.9% Sodium Chloride Solution in glass-bottles
•     5.0% Glucose Solution in glass-bottles
•     Ringer Lactate Solution in glass-bottles
•     0.9% Sodium Chloride Solution in PVC-bags
•     Ringer Lactate Solution in PVC-bags
•     5.0% Dextrose Solution in PVC-bags
•     5.0% Dextrose + 0.45% Sodium Chloride Solution in PVC-bags
•     Ringer Lactate Solution in PE-bottles
•     5.0% Dextrose + 0.45% Sodium Chloride Solution in PE-bottles 

Discard any unused remaining solution

6.5 Nature and contents of container
Ampoules of 4 mL:
1 ampoule
15 ampoules
Hospital pack with 50 ampoules

6.6 Instructions for use and handling
No special requirements.