Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1 Pharmacodynamic properties
Pharmacotherapeutic group: Chemotherapy agent for topical use, antiviral agents ATC code: D06BB04

Podophyllotoxin is the therapeutic ingredient of podophyllin, the resin from the rootstock of the pododphyllum species (Berberidaceae).
Podophyllotoxin has a marked antimitotic effect. Binding to tubulin prevents the formation of microtubules and thus spindle formation in the metaphase of cell division. Necrosis of the wart tissue is caused by blocked cell division.

In addition, podophyllotoxin has a tumour-destructive and anti-inflammatory effect.

Pharmacokinetic Properties

5.2 Pharmacokinetic properties
Since podophyllotoxin is only absorbed to a low degree when applied locally, no systemic effects are expected with the recommended route of administration and dosage.
The absorbed amount of topically applied podophyllotoxin depends on the application volume.
Amounts up to 50 μl of a 0.5% ethanolic solution (corresponds to Condylox) were not detectable in the serum. Patients treated with 100-1500 μl showed serum peak values of 1-17 ng/ml within 1 to 2 hours. There was no accumulation of the substance in the serum.
The half-life of podophyllotoxin is 1-4.5 hours.
Use of up to 250 μl twice daily for 3 days is considered safe and does not result in systemic toxicity.