Posology : מינונים

4.2 Posology and method of administration

Posology

Use in adult men
The recommended dose is 10 mg taken as needed approximately 25 - 60 minutes before sexual activity.
Based on efficacy and tolerability the dose may be increased to 20 mg or decreased to 5 mg. The maximum recommended dose is 20 mg. The maximum recommended dosing frequency is once per day.
Levitra can be taken with or without food. The onset of activity may be delayed if taken with a high fat meal (see section 5.2).

Special populations
Elderly (>65 years old)
Dose adjustments are not required in elderly patients. However, an increase to a maximum 20 mg dose should be carefully considered depending on the individual tolerability (see sections 4.4 and 4.8).

Hepatic impairment
A starting dose of 5 mg should be considered in patients with mild and moderate hepatic impairment (Child-Pugh A-B). Based on tolerability and efficacy, the dose may subsequently be increased. The maximum dose recommended in patients with moderate hepatic impairment (Child-Pugh B) is 10 mg (see sections 4.3 and 5.2).

Renal impairment
No dose adjustment is required in patients with mild to moderate renal impairment.
In patients with severe renal impairment (creatinine clearance <30 ml/min), a starting dose of 5 mg should be considered. Based on tolerability and efficacy the dose may be increased to 10 mg and 20 mg.

Paediatric population
Levitra is not indicated for individuals below 18 years of age. There is no relevant indication for use of Levitra in children.

Use in patients using other medicinal products
Concomitant use of CYP3A4 inhibitors
When used in combination with the CYP3A4 inhibitors such as erythromycin or clarithromycin, the dose of vardenafil should not exceed 5 mg (see section 4.5).

Method of administration
For oral use.