Quest for the right Drug
אינדוביס כמוסות INDOVIS CAPSULES (INDOMETHACIN)
תרופה במרשם
תרופה בסל
נרקוטיקה
ציטוטוקסיקה
צורת מתן:
פומי : PER OS
צורת מינון:
קפסולות : CAPSULES
עלון לרופא
מינוניםPosology התוויות
Indications תופעות לוואי
Adverse reactions התוויות נגד
Contraindications אינטראקציות
Interactions מינון יתר
Overdose הריון/הנקה
Pregnancy & Lactation אוכלוסיות מיוחדות
Special populations תכונות פרמקולוגיות
Pharmacological properties מידע רוקחי
Pharmaceutical particulars אזהרת שימוש
Special Warning עלון לרופא
Physicians Leaflet
Pharmacological properties : תכונות פרמקולוגיות
Pharmacodynamic Properties
5.1 Pharmacodynamic properties ATC Code: M01AB01 Indovis is a non-steroidal anti-inflammatory agent with analgesic and antipyretic properties. The anti-inflammatory effect is due to inhibition of prostaglandin synthesis, which is does related and reversible. The analgesic properties have been attributed to both a central and peripheral effect, which are distinct from its anti-inflammatory activity.
Pharmacokinetic Properties
5.2 Pharmacokinetic properties Absorption: Indovis is rapidly and almost completely absorbed from the gastrointestinal tract; peak plasma concentrations are reached in about 0.5- 2 hours in fasting subjects, longer if taken with or after food. Distribution: More than 90% is bound to plasma proteins. It is distributed into synovial fluid, CNS and placenta. Low concentrations have been found in breast milk. The concentration in synovial fluid is equal to that in plasma within 5 hours. Indovis is largely converted to inactive metabolites. Metabolism: It is metabolised in the liver primarily by demethylation and deacetylation, it also undergoes glucuronidation and enterohepatic circulation. Enterohepatic cycling of metabolites, and probably indomethacin itself, occurs. Half-life in plasma is variable from 2 – 11 hours. Elimination: Mainly excreted in the urine, approximately 60%, the pH of the urine can affect this amount. Lesser amounts in the faeces. Indovis is also excreted in milk in small amounts.
שימוש לפי פנקס קופ''ח כללית 1994
Rheumatoid arthritis & osteoarthritis, acute gouty arthritis
תאריך הכללה מקורי בסל
01/01/1995
הגבלות
תרופה שאושרה לשימוש כללי בקופ'ח
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