Overdose : מינון יתר

9. OVERDOSAGE
Overdosage of desmopressin leads to an increased risk of prolonged fluid retention and hyponatremia.
Signs of overdosage may include nausea, headache, drowsiness, confusion, and rapid weight gain due to fluid retention [See Warnings and Precautions (5.1)].
In case of overdosage, NOQDIRNA must be discontinued, serum sodium assessed, and hyponatremia treated appropriately.


10     DESCRIPTION
NOQDIRNA is a sublingual tablet containing desmopressin acetate, a synthetic analog of the endogenous pituitary hormone, 8-arginine vasopressin (ADH), an antidiuretic hormone. It is chemically defined as follows:
Molecular weight of 1183.34 with the following empirical formula:
C46H64N14O12S2•C2H4O2•3H2O


SCH2CH2CO-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2 • CH3COOH • 3H2O
1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (salt) trihydrate.
NOQDIRNA (desmopressin acetate) sublingual tablets are available in two strengths. Each sublingual tablet contains desmopressin acetate, equivalent to 25 mcg or 50 mcg of desmopressin as free base, respectively. The inactive ingredients are gelatin, , mannitol, and anhydrous citric acid.