Special Warning : אזהרת שימוש

Precautions
In view of its pharmacology, known interactions and side effects, particular care should be observed when using Danol in patients with hepatic or renal disease, hypertension or other cardiovascular disease and in any state which may be exacerbated by fluid retention as well as in diabetes mellitus, polycythaemia, epilepsy, lipoprotein disorder, and in those who have shown marked or persistent androgenic reaction to previous gonadal steroid therapy.
Caution is advised in patients with migraine.
Until more is known, caution is advised in the use of Danol in the presence of known or suspected malignant disease (see also contra-indications). Before treatment initiation, the presence of hormone–dependent carcinoma should be excluded at least by careful clinical examination, as well as if breast nodules persist or enlarge during danazol treatment.
In addition to clinical monitoring in all patients, appropriate laboratory monitoring should be considered which may include periodic measurement of hepatic function and haematological state. For long-term treatment (> 6 months) or repeated courses of treatment, biannual hepatic ultrasonography is recommended.
Danazol should be initiated during menstruation. An effective, non-hormonal method of contraception should be employed (see Section 4.2 and 4.6 Pregnancy and Lactation).
The lowest effective dose of Danol should always be sought.



Effects on Driving

4.7   Effects on Ability to Drive and Use Machines
Danol has no or negligible influence on the ability to drive and use machines.