Contraindications : התוויות נגד

4      CONTRAINDICATIONS
RIZALT is contraindicated in patients with:
•   Ischemic coronary artery disease (angina pectoris, history of myocardial infarction, or documented silent ischemia), or other significant underlying cardiovascular disease [see Warnings and Precautions (5.1)].
•   Coronary artery vasospasm including Prinzmetal's angina [see Warnings and Precautions (5.1)].
•   History of stroke or transient ischemic attack (TIA) [see Warnings and Precautions (5.4)].
•   Peripheral vascular disease (PVD) [see Warnings and Precautions (5.5)].
•   Ischemic bowel disease [see Warnings and Precautions (5.5)].
•   Uncontrolled hypertension [see Warnings and Precautions (5.8)].
•   Recent use (i.e., within 24 hours) of another 5-HT1 agonist, ergotamine-containing medication, or ergot-type medication (such as dihydroergotamine or methysergide) [see Drug Interactions (7.2 and 7.3)].
•   Hemiplegic or basilar migraine [see Indications and Usage (1)].
•   Concurrent administration or recent discontinuation (i.e., within 2 weeks) of a MAO-A inhibitor [see Drug Interactions (7.5) and Clinical Pharmacology (12.3)].
•   Hypersensitivity to RIZALT or RIZALT RPD (angioedema and anaphylaxis seen) [see Adverse Reactions (6.2)].