Contraindications : התוויות נגד

4.3 Contraindications

Hypersensitivity to adrenaline, sympathomimetics or to any of the excipients listed in section 6.1.

However, the presence of sulphites and the possibility of allergic reactions do not prevent use of the medicinal product for the treatment of severe allergic reactions or in other emergency situations. The possibility that the patient may develop adverse reactions to sulphites should be considered in asthmatics who show a deterioration in respiratory function after administration of the solution (see section 4.4 Special warnings and precautions for use).

Use of this medicinal product is contraindicated in patients with cardiac insufficiency, cardiac dilatation, coronary insufficiency and in most patients with cardiac arrhythmias, as this would further increase the need for oxygen of the myocardium.
The use of adrenaline is generally contraindicated in cases of hyperthyroidism and in the presence of serious hypertension as these patients are more susceptible to the adverse effects of this medicinal product. Use should be avoided in patients with phaeochromocytoma, as they may develop severe hypertension.

The medicinal product is also contraindicated in patients with organic brain damage, such as cerebral arteriosclerosis, and in patients with angle-closure glaucoma.

Adrenaline should be avoided in patients undergoing anaesthesia with halogenated hydrocarbons (chloroform, trichloroethylene) or cyclopropane. Adrenaline should be used with extreme caution with other halogenated hydrocarbon anaesthetics, such as halothane.
Combination with this medicinal product can cause serious arrhythmias (see section 4.5 Interaction with other medicinal products and other forms of interaction).

Administration of adrenaline is contraindicated during labour. During the last month of pregnancy and during labour, adrenaline inhibits uterine tone and contractions.

There are, however, no absolute contraindications in extremely serious situations.