Overdose : מינון יתר

4.9     Overdose
After use of recommended doses no reports of emergency situations have arisen; moreover, the administration of this medicinal product can be discontinued at any time. If fluid balance is not accurately calculated and monitored, hyperhydration or dehydration may occur, with the resultant associated circulatory reactions. These may be manifest through changes in blood pressure, central venous pressure, heart rate, and pulmonary arterial pressure. In cases of hyperhydration congestive cardiac failure and/or pulmonary congestion may be induced.

In cases of hyperhydration, net fluid removal should be increased on the device used for continuous renal replacement therapy. In cases of marked dehydration, net fluid removal by the device used for continuous renal replacement therapy should be decreased or discontinued; alternatively, fluid resuscitation can be applied to restore the hydration status.

If too large volume is applied, this may result in disturbances of electrolyte concentrations and the acid-base-balance, e. g. an overdose of bicarbonate may occur if an inappropriate large volume of the solution for haemodialysis/haemofiltration is infused/administered. This could possibly lead to metabolic alkalosis, decrease of ionized calcium, or tetany.