Interactions : אינטראקציות

4.5    Interaction with other medicinal products and other forms of interaction

No interaction studies have been performed.
The correct dose of MULTIBIC potassium-free/2/3/4 mmol/l potassium and strict monitoring of clinical chemistry parameters and vital signs will avoid risks related to interactions with other medicinal products.

The following interactions are conceivable:
-    Toxic effects of digitalis may be masked by hyperkalaemia, hypermagnesaemia and hypocalcaemia. The correction of these electrolytes by continuous renal replacement therapy may precipitate signs and symptoms of digitalis toxicity, e.g. cardiac arrhythmia.
-    Electrolyte substitutions, parenteral nutrition and other infusions usually given in intensive care medicine interact with the serum composition and the fluid status of the patient. This must be considered during application of continuous renal replacement therapy.
-    Continuous renal replacement therapy may reduce the blood concentration of drugs, especially of drugs with a low protein binding capacity, with a small distribution volume, with a molecular weight below the cut-off of the haemofilter and of medicinal products adsorbed to the haemofilter. An appropriate revision of the dose of such medicinal products may be required.