Interactions : אינטראקציות

4.5        Interaction with other medicinal products and other forms of interaction

Hypercalcaemia in patients taking digitalis preparations may precipitate cardiac arrhythmias. Patients taking digitalis concurrently with alfacalcidol must therefore be closely monitored.

Patients on barbiturates or other anticonvulsants such as carbamazepine, phenytoin or primidone, may require an increased dose of Alpha D3 to produce the desired effect.

Absorption of alfacalcidol may be impaired by concurrent use of mineral oil (prolonged use), colestyramine, colestipol, sucralfate or large amounts of aluminium-based antacids.

Caution should be exercised in the use of magnesium-based antacids or laxatives for patients taking alfacalcidol who are on chronic renal dialysis.
Hypermagnesaemia may occur.

The risk of hypercalcaemia is increased in patients taking calcium-containing preparations or thiazide diuretics concurrently with alfacalcidol.

Alfacalcidol is a potent derivative of Vitamin D. Pharmacological doses of Vitamin D or its analogues should not be given during alfacalcidol treatment because of the possibility of additive effects and an increased risk of hypercalcaemia.