Posology : מינונים

4.2 Posology and method of administration
The dosage of glibenclamide is governed by the desired blood glucose level.

The dosage of glibenclamide must be the lowest possible dose which is effective.
Mistakes, e.g. forgetting to take a dose, must never be corrected by subsequently taking a larger dose.

The usual total daily dosage is 2.5mg to 15mg daily with a usual initial dose of 5mg daily. Weekly adjustments can be made to increase the dosage to the optimal level. Doses of 10mg or less may be taken as a single dose immediately before breakfast, but should the daily dose exceed 10mg, the remainder should be taken immediately before the evening meal.

The elderly usually require lower dosage.

Dose Omission
A physician should be consulted in the event that a dose has not been taken at the prescribed time, a meal has been skipped or an extra dose has been taken.

It is very important not to skip meals after the tablets have been taken.

Secondary dosage adjustment
As an improvement in control of diabetes is, in itself, associated with higher insulin sensitivity, glibenclamide requirements may fall as treatment proceeds. To avoid hypoglycaemia, timely dose reduction or cessation of GLUBEN therapy must therefore be considered.

Correction of dosage must also be considered, whenever:

- the patients weight changes
- the patients life-style changes

- other factors arise, which cause an increased susceptibility to hypoglycaemia or hyperglycaemia.

Changeover from other oral antidiabetics to GLUBEN

Change over from other oral antidiabetic agents to GLUBEN should be done under the supervision of a specialist, and due to the potential summation of effects of both medications, entails a risk of hypoglycaemia. A break from medication may therefore be required when changing over medications. This should be decided by the attending physician.