Adverse reactions : תופעות לוואי

4.8    Undesirable effects

The most commonly reported adverse events of β2-agonist therapy, such as tremor and palpitations, tend to be mild and disappear within a few days of treatment.
Adverse reactions, which have been associated with formoterol are given below, listed by system organ class and frequency. Frequency are defined as: very common (≥1/10), common (≥1/100 and <1/10), uncommon (≥1/1 000 and <1/100), rare (≥1/10 000 and <1/1000) and very rare <1/10 000).
Cardiac disorders               Common      Palpitations

Uncommon    Tachycardia

Rare        Cardiac arrhythmias, e.g. atrial fibrillation, supraventricular tachycardia, extrasystoles.
Very rare   Angina pectoris, Prolongation of
QTc-interval

Gastrointestinal                Rare        Nausea disorders

Immune system                   Rare        Hypersensitivity reactions, e.g.
disorders                                   bronchospasm, exanthema, urticaria, pruritus

Metabolic and nutrition         Rare        Hypokalemia disorders
Very rare   Hyperglycemia

Musculoskeletal,                Uncommon    Muscle cramps connective tissue and bone disorders
Nervous system                  Common      Headache, tremor disorders
Very rare   Taste disturbances, dizziness

Psychiatric disorders           Uncommon    Agitation, restlessness, sleep disturbances

Vascular disorders              Very rare   Variations in blood pressure OXIS TURBUHALER             31 5. 2012, RH
As with all inhalation therapy, paradoxical bronchospasm may occur in very rare cases (see section 4.4.).


Treatment with β2-agonists may result in an increase in blood levels of insulin, free fatty acids, glycerol and ketone bodies.

The excipient lactose contains small amounts of milk proteins. These may cause allergic reactions.