Adverse reactions : תופעות לוואי

4.8 Undesirable effects
Most adverse effects are mild and tend to diminish with continued therapy.
Adverse events have been ranked under headings of frequency using the following convention: very common (≥ 1/10), common (≥ 1/100, < 1/10), uncommon (≥ 1/1,000, < 1/100), rare (≥1/10,000, < 1/1,000), very rare (< 1/10,000) and unknown (cannot be calculated from the available data).

Cardiac disorders:
Bradyarrhythmia: not known sinus bradycardia:uncommon
AV-block: rare
Nervous system disorders:
Dizziness, Sedation: very common
Headache: common
Paraesthesia: uncommon

Eye disorders:
Lacrimation decreased: rare.
Accommodation disorder: not known
Respiratory, thoracic and mediastinal disorders:
Nasal dryness: rare

Gastrointestinal disorders:
Dry mouth: very common
Constipation, Nausea, Salivary gland pain, Vomiting: common
Colonic pseudo-obstruction: rare

Skin and subcutaneous tissue disorders:
Pruritus, Rash, Urticaria: uncommon
Alopecia: rare
Vascular disorders:
Orthostatic hypotension: very common
Raynaud's phenomenon: uncommon

General disorders and administration site conditions:
Fatigue: common
Malaise: uncommon

Reproductive system and breast disorders:
Erectile dysfunction: common
Endocrine disorders:
Gynaecomastia: rare

Psychiatric disorders:
Sleep disorder, depression: common
Hallucination, delusional perception, nightmare: uncommon
Confusional state, libido decreased: not known

Investigations:
Blood glucose increased: rare
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit / risk balance of the medicinal product.
Any suspected adverse events should be reported to the Ministry of Health according to the National Regulation by using an online form: https://sideeffects.health.gov.il/