Posology : מינונים

4.2 Posology and method of administration
Route of administration: intramuscular or intravenous                                             Anti-gout: Probenecid has been shown to reduce the renal clearance of
furosemide and may increase, decrease or have no effect on the overall diuresis.
Adults                                                                                           Furosemide may reduce the renal clearance of probenecid. In case of high-dose
treatment (with furosemide and probenecid), this may lead to increased serum
Intravenous furosemide must be injected or infused slowly; a rate of 4 mg per                    levels and an increased risk of adverse effects.
minute must not be exceeded. In patients with severe impairment of renal function
(serum creatinine >5 mg/dl), it is recommended that an infusion rate of 2.5 mg per               Antihistamines: Hypokalaemia increases risk of ventricular arrhythmias with
minute is not exceeded.                                                                          terfenadine.

Intramuscular administration must be restricted to exceptional cases where neither               Antihypertensives: Furosemide enhances the hypotensive action of other
oral nor intravenous administration are feasible. It must be noted that                          antihypertensive drugs, including beta-blockers, calcium-channel blockers and
intramuscular injection is not suitable for the treatment of acute conditions such as            hydralazine. The dosage of currently administered antihypertensive agents may
pulmonary oedema.                                                                                require adjustment. There is an increase risk of firstdose hypotension with alpha blockers such as prazosin or angiotensin-converting enzyme (ACE) inhibitors
To achieve optimum efficacy and suppress counter-regulation, a continuous                        such as captopril. Particular care should be taken with ACE inhibitors and
furosemide infusion is generally to be preferred to repeated bolus injections.                   angiotensin-II antagonists when initiating or increasing their dose in concomitant Where continuous furosemide infusion is not feasible for follow-up treatment after               therapy with furosemide, since combination can result in marked reduction in blood one or several acute bolus doses, a follow-up regimen with low doses given at                    pressure and deterioration in renal function. The dose of furosemide should be short intervals (approx. 4 hours) is to be preferred to a regimen with higher bolus              reduced for at least three days, or the drug stopped, before initiating or increasing doses at longer intervals.                                                                       the dose of an ACE inhibitor or angiotensin II receptor antagonist. Long term
intensive treatment with captopril can enhance the natriuretic response to
Doses of 20 to 50 mg intramuscularly or intravenously may be given initially. If                 furosemide.
larger doses are required, they should be given increasing by 20 mg increments
and not given more often than every two hours. If doses greater than 50 mg are                   Antipsychotics: Hypokalaemia increases risk of ventricular arrhythmias with
required it is recommended that they be given by slow intravenous infusion. The                  primozide and sertindole, concurrent use should be avoided. Enhanced
recommended maximum daily dose of furosemide administration is 1,500 mg.                         hypotensive effect with phenothiazines.

Elderly: The dosage recommendations for adults apply, but in the elderly                         Risperidone: Caution should be exercised and the risks and benefits of the
furosemide is generally eliminated more slowly. Dosage should be titrated until the              combination or cotreatment with furosemide or with other potent diuretics should required response is achieved.                                                                   be considered prior to the decision to use. See section 4.4 Special warnings and precautions for use regarding increased mortality in elderly patients with dementia
Children: Parenteral doses for children range from 0.5 to 1.5 mg/kg body weight                  concomitantly receiving risperidone.
daily up to a maximum total daily dose of 20 mg.
Anxiolytics and hypnotics: Administration of chloral hydrate followed by