Posology : מינונים

4.2 Posology and method of administration
Adeno-Avenir is intended for hospital use only with monitoring and cardiorespiratory resuscitation equipment available for immediate use.
Method of administration
It should be administered by rapid IV bolus injection according to the ascending dosage schedule below. To be certain the solution reaches the systemic circulation administer either directly into a vein or into an IV line. If given into an IV line it should be injected as proximally as possible and followed by a rapid saline flush.
Adeno-Avenir should only be used when facilities exist for cardiac monitoring. Patients who develop high-level AV block at a particular dose should not be given further dosage increments.

Therapeutic dose
Adult:
Initial dose:       3 mg given as a rapid intravenous bolus (over 2 seconds).
Second dose:        If the first dose does not result in elimination of the supraventricular tachycardia within 1 – 2 minutes, 6 mg should be given also as a rapid intravenous bolus.
Third dose:         If the second dose does not result in elimination of the supraventricular tachycardia within 1 – 2 minutes. 12 mg should be given also as a rapid intravenous bolus.
Additional or higher doses are not recommended.

Children:
The level of evidence does not allow a recommended posology.

Elderly
See dosage recommendations for adults.
Hepatic / Renal impairment:
As Adenosine requires no hepatic or renal function for its activation or inactivation, hepatic and/or renal failure would not be expected to alter efficacy or tolerance.