Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1 Pharmacodynamic properties
Desoren solution is a bactericidal preparation active against all the pathogens commonly found in bacterial infections of the ear. Polymixin B is bactericidal against a wide range of gram negative bacilli including Pseudomonas Spp., Escherichia coli, Enterobacter Spp., Klebsiella Spp., and Haemophilus influenzae. It exerts a bactericidal effect by binding to acid phospholipids in the cell wall and membranes of the bacterium, thereby rendering ineffective the osmotic barrier normally provided by the cell membrane. This leads to escape of the cell contents and the death of the organism.

Neomycin sulphate is bactericidal against a wide range of gram positive and negative bacterial pathogens including Staphylococci, Streptococci, Escherichia, Enterobacter, Klebsiella, Haemophilus, Proteus, Salmonella and Shigella species. It is also active against some strains of the Pseudomonas aeruginosa and against Mycobacterium tuberculosis and Neisseria gonorrhoea. Neomycin exerts its bactericidal effect by interfering with the protein synthesis of susceptible organisms.

Pharmacokinetic Properties

5.2 Pharmacokinetic properties

No data are available regarding the pharmacokinetics of this product.
However since this is a topical preparation and significant systemic absorption is unlikely to occur, the data are irrelevant.
Systemically absorbed neomycin is predominantly excreted by the kidney and the total amount excreted in the urine varies between 30% and 50%. The pharmacokinetics of systemically absorbed polymixin B has been described.