Quest for the right Drug
דרמובט תמיסה לקרקפת DERMOVATE SCALP APPLICATION (CLOBETASOL PROPIONATE)
תרופה במרשם
תרופה בסל
נרקוטיקה
ציטוטוקסיקה
צורת מתן:
קרקפת - חיצוני : TOPICAL- SCALP
צורת מינון:
תמיסה - חיצוני : SOLUTION - EXTERNAL
עלון לרופא
מינוניםPosology התוויות
Indications תופעות לוואי
Adverse reactions התוויות נגד
Contraindications אינטראקציות
Interactions מינון יתר
Overdose הריון/הנקה
Pregnancy & Lactation אוכלוסיות מיוחדות
Special populations תכונות פרמקולוגיות
Pharmacological properties מידע רוקחי
Pharmaceutical particulars אזהרת שימוש
Special Warning עלון לרופא
Physicians Leaflet
Pharmacological properties : תכונות פרמקולוגיות
Pharmacodynamic Properties
5.1. Pharmacodynamic properties Pharmacotherapeutic group: Corticosteroids, very potent (group IV), ATC code: D07AD Mechanism of action Topical corticosteroids act as anti-inflammatory agents via multiple mechanisms to inhibit late phase allergic reactions including decreasing the density of mast cells, decreasing chemotaxis and activation of eosinophils, decreasing cytokine production by lymphocytes, monocytes, mast cells and eosinophils, and inhibiting the metabolism of arachidonic acid. Pharmacodynamic effects Topical corticosteroids have anti-inflammatory, antipruritic, and vasoconstrictive properties.
Pharmacokinetic Properties
5.2. Pharmacokinetic properties Absorption Topical corticosteroids can be systemically absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption. Distribution The use of pharmacodynamic endpoints for assessing the systemic exposure of topical corticosteroids is necessary due to the fact that circulating levels are well below the level of detection. Metabolism Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. They are metabolised, primarily in the liver. Elimination Topical corticosteroids are excreted by the kidneys. In addition, some corticosteroids and their metabolites are also excreted in the bile.
שימוש לפי פנקס קופ''ח כללית 1994
Very potent topical corticosteroid. Short term treatment only of severe exacerbations in inflammatory skin disorders such as discoid lupus erythematosus, lichen planus and psoriasis, unresponding to less potent corticosteroids
תאריך הכללה מקורי בסל
01/01/1995
הגבלות
תרופה שאושרה לשימוש כללי בקופ'ח
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