Contraindications : התוויות נגד

5            Contraindications
Known hypersensitivity to nitroglycerin and related organic nitrates or any excipient of Nitroderm TTS.
Acute circulatory failure associated with marked hypotension (shock).
Conditions associated with elevated intracranial pressure.
Myocardial insufficiency due to obstruction, as in aortic or mitral stenosis or constrictive pericarditis.
Concomitant use of Nitroderm TTS and phosphodiesterase type 5 (PDE5) inhibitors such as sildenafil is contraindicated, because PDE5 inhibitors may amplify the vasodilatory effects of Nitroderm TTS resulting in severe hypotension. The time course and dose dependence of this interaction have not been studied. Appropriate supportive care has not been studied, but it seems reasonable to treat this as a nitrite overdose, with elevation of the extremities and with central volume expansion.
Severe hypotension (systolic blood pressure less than 90 mmHg).
Severe hypovolemia.
The onset of action of transdermal nitroglycerin is not sufficiently rapid for this product to be useful in aborting an acute attack.
Allergy to the adhesives used in nitroglycerin patches has also been reported, and it similarly constitutes a contraindication to the use of this product.

6            Warnings and precautions