Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1   Pharmacodynamic properties

Pharmacotherapeutic group: Solutions for parenteral nutrition/combinations ATC code: B05 BA10.

TRIOMEL 7 g/l nitrogen 1140 kcal/l, emulsion for infusion’s content in nitrogen (L series amino acids) and energy (glucose and triglycerides) enables maintaining an adequate nitrogen/energy balance.

This formulation without electrolytes allows individual electrolyte intake to be adapted to meet specific requirements.

The lipid emulsion included in TRIOMEL 7 g/l nitrogen 1140 kcal/l, emulsion for infusion is an association of refined olive oil and refined soya-bean oil (ratio 80/20), with the following approximate distribution of fatty acids:
-      15% saturated fatty acids (SFA)
-      65% monounsaturated fatty acids (MUFA)
-      20% polyunsaturated essential fatty acids (PUFA)

The phospholipid/triglyceride ratio is 0.06.

Olive oil contains significant amounts of alpha-tocopherol which, combined with a moderate PUFA intake, contribute to improved vitamin E status and the reduction of lipid peroxidation.

The amino acid solution contains 17 L-series amino acids (including 8 essential amino acids), which are required for protein synthesis.
Amino acids also represent an energy source. Their oxidation results in excretion of nitrogen in the form of urea.

The amino acid profile is as follows:
-    Essential amino acids/total amino acids: 44.8%
-    Essential amino acids (g)/total nitrogen (g): 2.8%
-    Branched-chain amino acids/total amino acids: 18.3%

The carbohydrate source is glucose.

Pharmacokinetic Properties

5.2   Pharmacokinetic properties

The ingredients of TRIOMEL 7 g/l nitrogen 1140 kcal/l, emulsion for infusion (amino acids, glucose and lipids) are distributed, metabolised and removed in the same way as if they had been administered individually.