Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1   Pharmacodynamic properties
Pharmacotherapeutic group: herbal medicine for the treatment of menstrual disorders ATC-Code: G02CX03
There is evidence that aqueous-alcoholic Agni casti fructus extracts inhibit prolactin release in vitro. The inhibitory effect on prolactin release was also confirmed in animal experiments. In human pharmacology there is yet no data to support a lowering of elevated prolactin levels. However, several clinical studies showed evidence that slightly elevated prolactin levels in women and increased prolactin release due to stress (so-called "latent hyperprolactinaemia") are reduced through administration of Agnus castus extract.

In vitro studies showed that the lactotrophic pituitary cells are the site of action and the mechanism of action is dopaminergic.

Bicyclic diterpenes have been identified as a substance group that contributes to the prolactin reducing effects of Agni casti fructus extract BNO 1095. These substances bind to the human dopamine receptor subtype 2 and lower in a concentration-dependent manner the prolactin release in cultured rat pituitary cells.

Pharmacokinetic Properties

5.2   Pharmacokinetic properties

There are no studies on pharmacokinetics and bioavailability because not all active sub- stances are known in detail.