Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1.   Pharmacodynamic properties
Pharmacotherapeutic group: herbal medicinal product for acute bronchitis
ATC- code: R05CP05 other cough and cold preparations
ATC - code: R05X

Kaloba® tablets contain an extract from the roots of Pelargonium sidoides, a plant which is indigenous to South Africa.
In animal experiments, inhibition of “sickness behaviour” (unspecific illness symptoms occurring in the context of an infection) and antioxidative properties could be demons- trated after oral application of the extract in mice.
In vitro, the following effects have been verified for Kaloba® tablets: Stimulation of unspecific defence mechanisms:
− stimulation of ciliary beat frequency of epithelial cells,
− modulation of interferon synthesis and proinflammatory cytokines, − stimulation of activity of NK-cells
− stimulation of phagocytes, expression of adhesion molecules, chemotaxis.



Antimicrobial effects:
− moderate direct antibacterial and antiviral properties
− increase/inhibition of adhesion of A-streptococci to desquamated/living epithelial cells
− inhibition of ß-lactamase.
Cytoprotective properties:
− inhibition of human leukocyte elastase
− antioxidative properties.

Pharmacokinetic Properties

5.2.   Pharmacokinetic properties
Kaloba® tablets are a complex mixture of a multitude of components which, as a whole, are to be considered as the active substance. Pharmacokinetic data on the individual substances are not yet available.