Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
ADACEL-POLIO may be administered concomitantly with a dose of inactivated influenza vaccine, based on the results of a clinical trial conducted in persons 60 years of age and older.
ADACEL-POLIO may be administered concomitantly with a dose of hepatitis B vaccine.
ADACEL-POLIO may be administered concurrently with a dose of recombinant Human Papillomavirus vaccine with no significant interference with antibody response to any of the components of either vaccine. However, a trend of lower anti-HPV GMTs was observed in the concomitant group. The clinical significance of this observation is not known. This is based on the results from a clinical trial in which ADACEL-POLIO was administered concomitantly with the first dose of Gardasil (see section 4.8).
Separate limbs must be used for the site of injection. Interaction studies have not been carried out with other vaccines, biological products or therapeutic medications.
However, in accordance with commonly accepted immunization guidelines, since ADACEL-POLIO is an inactivated product it may be administered concomitantly with other vaccines or immunoglobulins at separate injection sites.
In the case of immunosuppressive therapy please refer to Section 4.4.