Posology : מינונים

4.2.   Posology and method of administration
The dose depends on the degree of the disorder of the acid-base status. According to the blood gas values the amount to be administered is calculated applying the following formula: # ml of 1 M (8.4 % w/v) sodium bicarbonate solution = base deficit x kg b.w.
x 0.3

(The factor 0.3 corresponds to the proportion of the extracellular fluid in relation to total body fluid).

Example:
If in a patient of 70 kg b.w. the base deficit is 5 mmol/l, then 5 x 70 x 0.3 = 105 ml of Sodium Bicarbonate 8.4% are to be given.

In neonates and infants the daily dose should not exceed 8 mmol/kg BW/day, administered by slow intravenous infusion, dosage and infusion rate should be controlled carefully.

Correction of metabolic acidosis should not be effected too rapidly. It is advisable to start administering only half of the calculated dose and adjust further doses according to the actual results of blood gas analysis.

For urine alkalisation the dose is adjusted according to the desired pH of the urine and administration should be accompanied by monitoring of the acidbase balance and the water balance. Care should be taken not to exceed the maximum infusion rate stated below.

Maximum daily dose:

According to the correction requirements.
Flow rate:

Up to 1.5 mmol of sodium bicarbonate per kg body weight per hour, corresponding to 1.5 ml of Sodium Bicarbonate 8.4%/kg bw/h.

Method of administration:

Intravenous use.
The solution must be infused into a central vein.