Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1. Pharmacodynamic Properties
Pharmacotherapeutic group: “Electrolytes” - ATC code: “B05BB01” 
Plasma-Lyte 148 (pH 7.4) is an isotonic solution of electrolytes. The electrolytes constituents of Plasma-Lyte 148 (pH 7.4) solution and their concentrations are designed to match those of plasma.

The pharmacological properties of Plasma-Lyte 148 (pH 7.4) solution are those of its components (water, sodium, potassium, magnesium, chloride, acetate and gluconate).
The main effect of Plasma-Lyte 148 (pH 7.4) is the expansion of the extracellular compartment including both the interstitial fluid and the intravascular fluid.

Sodium acetate and gluconate are bicarbonate-producing salts and as such are alkalinizing agents.

When medication is added to Plasma-Lyte 148 (pH 7.4), the overall pharmacodynamics of the solution will depend on the nature of the drug used.

Pharmacokinetic Properties

5.2. Pharmacokinetic Properties

The pharmacokinetic properties of the Plasma-Lyte 148 (pH 7.4) solution are those of the ions its composition includes (sodium, potassium, magnesium, chloride, acetate and gluconate).

Acetates are metabolised by muscle and peripheral tissues to bicarbonate, without solicitation of the liver.

When medication is added to Plasma-Lyte 148 (pH 7.4), the overall pharmacokinetics of the solution will depend on the nature of the drug used.