Posology : מינונים

4.2   Posology and method of administration
The dosage is dependent on age, weight and clinical condition of the patient, especially those with renal or cardiac insufficiency. Dosage and rate of infusion should be determined by ECG and serum electrolyte monitoring.
Adequate urine flow must be ensured.
Adults:
The following recommendations are general guidelines on potassium.
Potassium
The amount required for correction of moderate potassium deficiency and in maintenance may be calculated according to the following formula: mmol K+required = (body weight [kg] × 0.2)* × 2 × (serum-K+target** – serum- K+actual [mmol/l])
*Term represents the extracellular fluid volume
** should be 4.5 mmol/l
The maximum recommended dose of potassium is 2 – 3 mmol/kg b.w./24 h.
Fluids
Generally, not more than 40 ml fluid/kg b.w./day should be supplied. In cases where more potassium is needed, other strengths should be considered as well.
Paediatric population
The volume and rate of infusion will depend upon the requirements of the individual patient.
Reduced volumes and rates of infusion may be required. Generally a substitution rate of 0.5 mmol/kg bw per hour should not be exceeded. Continuous ECG monitoring should be applied during infusion.


Maximum daily dose
The maximum recommended dose of potassium is 3 mmol/kg BW per 24 hours. In any case the limits for daily fluid intake must not be exceeded.

Elderly

Basically the same dosage as for adults applies, but caution should be exercised in patients suffering from further diseases like cardiac insufficiency or renal insufficiency that may frequently be associated with advanced age. See section 4.

Infusion rate
The infusion rate will depend on the conditions of the individual patient (see section 4.4) In patients with chronic hyponatraemia the rate of infusion should be slow, so that the resulting increase of the serum sodium level is limited to a maximum of 0.35 mmol/l/h.

Duration of use
This medicinal product may be administered as long as there is an indication for electrolyte and fluid administration.

Method and route of administration
Intravenous use.
The maximum rate of Potassium Chloride 0.3% w/v and Sodium Chloride 0.9% w/vadministration via peripheral lines is 10 mmol potassium per hour. For greater infusion rates, the solutions should be infused via a central line.
As a matter of principle, infusion pumps should be used for the infusion of potassium in the setting of correction therapy.