Posology : מינונים

4.2      Posology and method of administration

There are no age restrictions on the use of Ursofalk 250 capsules.
The following daily dose is recommended for the various indications: 
For the treatment of primary biliary cirrhosis (PBC)
The daily dose depends on body weight, and ranges from 3 to 7 capsules (14 ± 2 mg UDCA per kg of body weight). For the first 3 months of treatment, Ursofalk 250 capsules should be taken in divided doses throughout the day. When the liver function parameters improve, the daily dose may be taken once daily in the evening.

Body              Ursofalk 250 capsules weight (kg)       first 3 months                         subsequently morning       midday         evening   evening
(1 x daily)
47 – 62           1            1               1         3
63 – 78           1            1               2         4
79 – 93           1            2               2         5
94 – 109          2            2               2         6
Over 110          2            2               3         7

The capsules should be swallowed whole with some liquid. Ursofalk 250 capsules must be taken regularly.
The use of Ursofalk 250 capsules in PBC may be continued indefinitely.

In patients with PBC, in rare cases the clinical symptoms may worsen at the beginning of treatment, e.g. the itching may increase. In this event, therapy should first be continued with one Ursofalk 250 capsule daily, and the dose then gradually increased (weekly increase of the daily dose by one capsule) until the dose indicated in the respective dosage regimen is reached again.

General recommendation for PSC:
10 to 15 mg/kg/day administered in 2 to 4 divided doses.
The dose may be adjusted according to the patient's age and severity of symptoms