Posology : מינונים

4.2.   Posology and method of administration

Posology
Unless otherwise directed the following dosage guidelines are recommended: Adults and children over 12 years:
Maintenance dose:
Approximately 7.5 mg Metronidazole/kg body weight over one hour every 8 hours, corresponding to 100 ml (500 mg) Metronidazole injection for a 70 Kg adult.
Loading dose: 15 mg/kg infused over one hour (approximately 1 g for 70 kg adult): A maximum of 1.4 g should not be exceeded during 24 hours.
Safety and effectiveness in children have not been established.
In renal insufficiency the dose interval is to be extended to 12 hours.
In severe hepatic disease plasma metronidazole levels have to be monitored. The usually recommended dose may eventually have to be reduced.
Method of Administration
The contents of 1 bottle are to be infused slowly I. V., i.e. 100 ml max. in 20 minutes but usually in 60 minutes.
For preventive therapy prior to operations it is recommended to administer the single dose unit of 500 mg shortly before starting operation.
Administration can also be performed in a diluted form by adding the product to an I.V. carrier solution such as 0.9 % sodium chloride or 5 % dextrose injection.
Simultaneously prescribed antibiotics are to be administered separately.
Open bottles with unused portions shall not be stored but discarded.
Do not use equipment containing aluminum that would come in contact with the drug solution.
Duration of therapy
The duration of therapy should not exceed 10 days.
However, in special, well-founded cases the treatment may be extended.
Repeat therapy should be restricted as much as possible and to specific elective cases only.
This limitation must be strictly observed because the possibility of metronidazole developing mutagenic and carcinogenic activity cannot be safely excluded.
Prophylactic use should be discontinued within 12 hours after surgery. If there are signs of infection, obtain specimens for cultures to identify the causative organisms.