Interactions : אינטראקציות

7     DRUG INTERACTIONS
7.1    Clinically Important Drug Interactions With Metadex XR
Table 5 presents clinically important drug interactions with Metadex XR.

Table 5: Clinically Important Drug Interactions With Metadex XR
Monoamine Oxidase Inhibitors (MAOIs)
Clinical Impact Concomitant use of MAOIs and CNS stimulants, including Metadex XR, can cause hypertensive crisis. Potential outcomes include death, stroke, myocardial infarction,
aortic dissection, ophthalmological complications,
eclampsia, pulmonary edema, and renal failure [see
Contraindications (4)].
Intervention    Concomitant use of Metadex XRwith MAOIs or within 14 days after discontinuing MAOI treatment is contraindicated.
Examples        selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue
Antihypertensive Drugs
Clinical Impact Metadex XRmay decrease the effectiveness of drugs used to treat hypertension [see Warnings and
Precautions (5.3)].
Intervention    Monitor blood pressure and adjust the dosage of the antihypertensive drug as needed.
Examples        Potassium-sparing and thiazide diuretics, calcium channel blockers, angiotensin-converting-enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta blockers, centrally acting alpha-2 receptor agonists
Halogenated Anesthetics
Clinical Impact Concomitant use of halogenated anesthetics and
Metadex XR may increase the risk of sudden blood pressure and heart rate increase during surgery.
Intervention    Avoid use of Metadex XRin patients being treated with anesthetics on the day of surgery.
Examples        halothane, isoflurane, enflurane, desflurane, sevoflurane Risperidone
Clinical Impact Combined use of methylphenidate with risperidone when there is a change, whether an increase or decrease, in dosage of either or both medications, may increase the risk of extrapyramidal symptoms (EPS).
Intervention    Monitor for signs of EPS.