Posology : מינונים

4.2 Posology and method of administration

Duration of treatment
The duration of treatment depends on the response of the pathogen and the clinical condition. Basically, it is advisable to continue the treatment for at least three days after the resolution of fever and the disappearance of symptoms.

In acute infections, treatment for 7 to 10 days is usually sufficient. The usual duration of treatment is 7-8 days for salmonellosis, 3-5 days for shigellosis and 3 days for intestinal infections with Escherichia coli.

Treatment with 200 mg ofloxacin per day for 3 days is usually sufficient for uncomplicated lower urinary tract infections. A single dose of 400 mg ofloxacin is adequate for the treatment of uncomplicated gonorrhea.

In the case of bone infections, the treatment lasts 3-4 weeks or even longer in some cases.

If infections with beta-hemolytic streptococci of proven sensitivity (e.g. erysipelas) are treated, this treatment must last for at least 10 days in order to prevent late complications such as rheumatic fever or glomerulonephritis. However, since the sensitivity of beta-hemolytic streptococci to ofloxacin varies, treatment of these infections requires sensitivity to be established in each individual case.

Until further experience is gained, it is advisable not to exceed a treatment time of 2 months.

Method of administration
Ofloxacin Teva 200 mg tablet should be swallowed whole, not chewed, and taken with adequate liquid (1/2 to 1 glass). They can be taken on an empty stomach or at mealtimes.

Up to 400 mg ofloxacin can be administered as a single dose. The daily dose is usually divided into two equal doses (morning and evening). It is important to ensure that the intervals between doses are similar in length. Single doses of up to 1 Ofloxacin Teva 400 mg tablet daily are best taken in the morning.

Indications                                 Single and daily doses
Uncomplicated      lower   urinary    tract 2 x ½ Ofloxacin Teva 200 mg tablet daily infections
Uncomplicated gonorrhea                  1 x 400 mg ofloxacin as a single daily dose, corresponding to 1x2 Ofloxacin
Teva 200 mg tablets
Infections of the kidneys, urinary tract 2 x 200 mg ofloxacin daily, and reproductive organs                  corresponding to 2x1 Ofloxacin Teva 200 mg tablet
Infections of the respiratory tract and of 2 x 200            mg ofloxacin daily, the ears, nose and throat                  corresponding     to 2x1 Ofloxacin Teva 200 mg tablet
Infections of the skin and soft tissues    2 x 200            mg ofloxacin daily, corresponding     to 2x1 Ofloxacin Teva
200 mg tablet


 Indications                                  Single and daily doses
Infections of the bones                      2 x 200 mg ofloxacin                  daily, corresponding to 2x1 Ofloxacin        Teva
200 mg tablet
Infections of the abdominal cavity           2 x 200 mg ofloxacin                  daily, (incl. bacterial diarrheas)                  corresponding to 2x1 Ofloxacin        Teva 200 mg tablet

In individual cases it may be necessary to increase the dose in the event of pathogens with different sensitivities, in severe infections (e.g. of the respiratory tract or bones) and if the patient's response is insufficient. In these cases the dose can be increased to 2 x 400 mg ofloxacin daily. The same applies to infections with concomitant complicating factors.

For the prophylaxis of infection in severely immunocompromised patients, 400 to 600 mg ofloxacin daily are recommended.

Dosage in patients with impaired kidney function
For patients with moderate to severe impairment of renal function as judged by creatinine clearance or serum creatinine it is advisable to use Ofloxacin Teva 200 mg tablets as they can be divided into two half tablets, each containing 100 mg ofloxacin.
The first dose depends on the nature and severity of the disease and is the same as for patients with normal renal function.

The maintenance dose should be reduced as follows:

Creatinine clearance          Serum creatinine           Maintenance dose 50 to 20 ml/min               1.5 to 5 mg/dl             100 to 200 mg ofloxacin daily ≤ 20 ml/min                   ≥ 5 mg/dl                  100 mg ofloxacin daily Hemodialysis or                                          100 mg ofloxacin daily peritoneal dialysis

In some cases (see above) it may be necessary to increase the above-mentioned dose.

Dosage in patients with impaired liver function
The excretion of ofloxacin may be diminished in patients with severe impairment of liver function (e.g. in the case of cirrhosis of the liver with ascites). It is therefore advisable not to exceed a maximum daily dose of 400 mg ofloxacin in such cases.

Children:
Ofloxacin Teva is not indicated for use in children or growing adolescents.