Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1   Pharmacodynamic properties
Pharmacotherapeutic group: Electrolytes
ATC code: B05B B01
This medicinal product is an isotonic electrolyte solution adapted to plasma electrolyte concentrations. It is used to correct extracellular fluid losses (i.e. losses of water and electrolytes in physiological amounts). The supply of this solution is aimed at restoring as well as maintaining normal osmotic conditions in the extracellular and intracellular space.
The anion pattern represents a balanced combination of chloride, acetate and malate, which counteracts metabolic acidosis.

Pharmacokinetic Properties

5.2   Pharmacokinetic properties
Absorption
Because the ingredients of Sterofundin ISO are infused intravenously, their bioavailability is 100 %.
Distribution and elimination
Sodium and chloride mainly distribute in the extracellular space, whereas potassium, magnesium and calcium distribute in the intracellular space.
The kidneys are the main route of excretion for sodium, potassium, magnesium and chloride, but small amounts are lost via the skin and intestinal tract. Calcium is excreted in approximately equal amounts in the urine and via intestinal secretion.
During the infusion of acetate and malate, their serum levels rise and appear to reach a steady state. Following termination of the infusion, the acetate and malate concentrations rapidly drop.


The renal excretion of acetate and malate rises during the infusion. However, their metabolism by body tissues is so rapid that only a small fraction appears in the urine.