Posology : מינונים

4.2       Posology and method of administration
Posology


Initial dose: 2.5 mg three times a day. Depending on the results of supine and standing blood pressure recordings, this dose may be increased weekly up to a dose of 10 mg three times a day. This is the usual maintenance dosage.


A careful evaluation of the response to treatment and of the overall balance of the expected benefits and risks needs to be undertaken before any dose increase and advice to continue therapy for long periods.
The last daily dose should be taken at least 4 hours before bedtime in order to prevent supine hypertension (see also section 4.4).


Midodrine Hydrochloride Morningside 2.5 mg tablets may be taken with food (see section 5.2).


Paediatric population
The safety and efficacy of midodrine hydrochloride in children and adolescents under the age of 18 years have not been established. No data are available.


Elderly population
There is limited data on dosing in the elderly and there are no specific studies which have focused on a possible dose reduction in the elderly population. Cautious dose titration is recommended.


Patients with renal impairment
There are no specific studies that have focused on a possible dose reduction in patients with renal impairment. Typically, midodrine hydrochloride is contraindicated in patients with acute renal impairment and severe renal impairment (see section 4.3).


Patients with hepatic impairment
There are no specific studies in this patient population (see also section 4.4).

Method of administration
For oral use.