Posology : מינונים

4.2 Posology and method of administration
As a general recommendation, the dose should be given for the shortest possible duration.
Because of their dosage strength, Abitren Supposotories 50 mg is not suitable for children and adolescents.

Generally 2 suppositories daily are recommended, usually administered at night. In more severe cases, combined therapy with tablets is recommended. The daily dose should not exceed 150 mg of diclofenac.

Special populations
Elderly
Although the pharmacokinetics of diclofenac sodium suppositories are not impaired to any clinically relevant extent in elderly patients, nonsteroidal anti-inflammatory drugs should be used with particular caution in such patients who generally are more prone to adverse reactions. In particular it is recommended that the lowest effective dosage be used in frail elderly patients or those with a low body weight (see also Precautions) and the patient should be monitored for GI bleeding during NSAID therapy.
Cardiovascular and significant cardiovascular risk factors
Diclofenac is contraindicated in patients with established congestive heart failure (NYHA II-IV), ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease (see section 4.3 Contraindications). Patients with congestive heart failure (NYHA-I) or significant risk factors for
cardiovascular disease should be treated with diclofenac only after careful consideration. Since cardiovascular risks with diclofenac may increase with dose and duration of exposure, the lowest effective daily dose should be used and for the shortest duration possible (see section 4.4 Special warnings and precautions for use).

Renal impairment
Diclofenac is contraindicated in patients with renal failure (see section 4.3). No specific studies have been carried out in patients with renal impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering diclofenac to patients with mild to moderate renal impairment (see section 4.4 Special warnings and precautions for use).
Hepatic impairment
Diclofenac is contraindicated in patients with hepatic failure (see section 4.3). No specific studies have been carried out in patients with hepatic impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering diclofenac to patients with mild to moderate hepatic impairment (see section 4.4 Special warnings and precautions for use).