Special Warning : אזהרת שימוש

4.4    Special warnings and precautions for use
Use in patients with renal impairment and in elderly patients:
Aciclovir is eliminated by renal clearance, therefore the dose must be adjusted in patients with renal impairment (see 4.2 Posology and Method of Administration).
Elderly patients are likely to have reduced renal function and therefore the need for dose adjustment must be considered in this group of patients. Both elderly patients and patients with renal impairment are at increased risk of developing neurological side effects and should be closely monitored for evidence of these effects. In the reported cases, these reactions were generally reversible on discontinuation of treatment (see 4.8 Undesirable Effects). Prolonged or repeated courses of aciclovir in severely immune-compromised individuals may result in the selection of virus strains with reduced sensitivity, which may not respond to continued aciclovir treatment (see section 5.1).


Hydration status: Care should be taken to maintain adequate hydration in patients receiving high oral doses of aciclovir.
This risk of renal impairment is increased by use with other nephrotoxic drugs.


The data currently available from clinical studies is not sufficient to conclude that treatment with aciclovir reduces the incidence of chickenpox-associated complications in immunocompetent patients.



Excipients
Zovirax Suspension contains Methyl parahydroxybenzoate and Propyl parahydroxybenzoate which may cause allergic reactions (possibly delayed).

Zovirax Suspension contains 1575 mg sorbitol per 5 mL. Hence Patients with rare hereditary problems of fructose intolerance should not take this medicine.

Effects on Driving

4.7    Effects on ability to drive and use machines
The clinical status of the patient and the adverse event profile of aciclovir should be borne in mind when considering the patients ability to drive or operate machinery.
There have been no studies to investigate the effect of aciclovir on driving performance or the ability to operate machinery. Further, a detrimental effect on such activities cannot be predicted from the pharmacology of the active substance.