Posology : מינונים

4.2 Posology and method of administration              4.5 Interaction with other medicinal products
Pre-anesthetic medication                              and other forms of interaction Adults: The recommended dose is 0.3-0.6 mg             Contraindicated associations by intravenous injection immediately before            Derivatives of Belladonna: increase of the the anesthesia induction or by intramuscular           anticholinergic activity.
injection 30-60 minutes before the induction.          Halothane: attenuation of the depressor Children: The recommended dose is 0.02 mg/kg           effect on heart rate.
(maximum dose 0.6 mg).                                 Procainamide: increased vagal effects at atrioventricular level.
Treatment of sinus bradycardia                         Methacholine: inhibition of the The recommended dose is between 0.3                    bronchoconstriction induced by methacholine and 1.0 mg intravenously.                              inhalation.

Antidote in poisoning by organophosphorus              Combinations to be taken into consideration Adults: The recommended dose is 2 mg                   Other drugs with anticholinergic activity, such (intramuscularly or intravenously, taking              as tricyclic antidepressants, some anti-H1 into account the poisoning severity) every             antihistamines, antiparkinsonian drugs, 5-10 minutes, until the skin becomes red and           disopyramide, mequitazine, phenothiazines, dry, pupils dilate and tachycardia appears.            neuroleptic drugs, atropine antispasmodics, Children: The recommended dose is                      clozapine and quinidine, due to the risk of 0.02 mg/kg.                                            intensification of atropine adverse effects (urinary retention, constipation, dry mouth).