Interactions : אינטראקציות

4.5     Interaction with other medicinal products and other forms of interaction

Propofol-Lipuro 2% has been used in association with spinal and epidural anaesthesia and with com- monly used premedicants, neuromuscular blocking drugs, inhalational agents and analgesic agents; no pharmacological incompatibility has been encountered. Lower doses of Propofol-Lipuro 2% may be required where general anaesthesia is used as an adjunct to regional anaesthetic techniques. Profound hypotension has been reported following anaesthetic with propofol in patients treated with rifampicin.

The concurrent administration of other CNS depressants such as pre-medication drugs, inhalation agents, analgesic agents may add to the sedative, anaesthetic and cardiorespiratory depressant effects of Propofol-Lipuro 2% (see Section 4.4).
A need for lower propofol doses has been observed in patients taking valproate.
When used concomitantly, a dose reduction of propofol may be considered.

A need for lower propofol doses has been observed in patients taking midazolam. The coadministra- tion of propofol with midazolam is likely to result in enhanced sedation and respiratory depression.
When used concomitantly, a dose reduction of propofol should to be considered.