Indications : התוויות

Therapeutic indications                 drugs associated with bone marrow
Typhus and parathyphus, salmonellosis        depression should not be prescribed with septic development, meningitis,         during the course of treatment with epiglottis, pertussis and parapertus-        chloramphenicol.
sis, serious infections with aerobe and anaerobe flora (pulmonary, abdominal,        By inhibition of microsomal enzymes gynecologic) and other infections            chloramphenicol reduces biodegrada- caused by bacteria susceptible to chlo-      tion and prolongs effect of phenytoin, ramphenicol.                                 some of the oral antidiabetics (tolbu- tamide, chlorpropamide) and indirect
Chloramphenicol VUAB 1 g can be              anticoagulants (warfarine, dicumarol).
used only in serious infections, for         During the concurrent treatment, dose which less potentially dangerous drugs       adjustment may be necessary.
are ineffective or are contraindicated
(see point 4.4. and 5.1.). Chlorampheni-     Phenobarbital and rifampicine could in- col is not indicated for neonates.           crease biodegradation of chlorampheni- col due to hepatic enzymes induction.
Official guidance for using of antibiotics must be taken in consideration.              Chloramphenicol increases plasma levels of tacrolimus, probably by inhi-