Contraindications : התוויות נגד

4 CONTRAINDICATIONS
Yaz Plus is contraindicated in females who are known to have or develop the following conditions:
•   Renal impairment
•   Adrenal insufficiency
•   A high risk of arterial or venous thrombotic diseases. Examples include women who are known to: o   Smoke, if over age 35 [see Boxed Warning and Warnings and Precautions (5.1)] o   Have deep vein thrombosis or pulmonary embolism, now or in the past [see Warnings and Precautions (5.1)] o   Have cerebrovascular disease [see Warnings and Precautions (5.1)] o   Have coronary artery disease [see Warnings and Precautions (5.1)] o   Have thrombogenic valvular or thrombogenic rhythm diseases of the heart (for example, subacute bacterial endocarditis with valvular disease, or atrial fibrillation) [see Warnings and Precautions (5.1)] o   Have inherited or acquired hypercoagulopathies [see Warnings and Precautions (5.1)] o   Have uncontrolled hypertension [see Warnings and Precautions (5.6)] o   Have diabetes mellitus with vascular disease [see Warnings and Precautions (5.8)] o   Have headaches with focal neurological symptoms or have migraine headaches with or without aura if over age 35 [see Warnings and Precautions (5.9)]
•   Undiagnosed abnormal uterine bleeding [see Warnings and Precautions (5.10)]
•   Current diagnosis of, or history of, breast cancer , which may be hormone-sensitive [see Warnings and Precautions (5.3)]
•   Liver tumors, benign or malignant, or liver disease [see Warnings and Precautions (5.4) and Use in Specific Populations (8.7)]
•   Use of Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to the potential for ALT elevations [see Warnings and Precautions (5.5) and Drug Interactions (7.3)].
•   Hypersensitivity to the active substance or to any of the excipients (inactive ingredients) listed in section 11.