Overdose : מינון יתר

4.9     Overdose
Symptoms of an overdose:
In cases of acute overdose, symptoms observed include nausea, vomiting, abdominal pain, impaired kidney function/acute renal failure (e.g., presenting as interstitial nephritis), and - less frequently - central nervous system symptoms (dizziness, somnolence, coma, seizures), as well as drops in blood pressure leading to shock and tachycardia.
Discharge of rubazonic acid might cause red discoloration of the urine after very high doses.
Treatment measures in the event of overdose
No specific antidote is known for Dipyrone. If Dipyrone has only been administered a short time ago, an attempt might be made to limit the resorption into the body by means of measures of detoxification (e.g. gastric lavage) or resorption-reducing measures (e.g. active carbon). The main metabolite (4-N methylamino-antipyrine) can be eliminated by means of hemodialysis, hemofiltration, hemoperfusion or plasma filtration.
Treatment of intoxication might, like prevention of severe complications, require general and specific intensive medical monitoring and care.
Immediate measures in the event of severe hypersensitivity reactions (shock) Stop the administration when the first signs (such as cutaneous reactions, urticaria and flush, restlessness, headaches, sweating, nausea) occur. In addition to common emergency measures such as Trendelenburg position, keeping respiratory tract free, application of oxygen, the administration of sympathomimetics, volume expanders or glucocorticoids may be necessary.