Contraindications : התוויות נגד

4.3     Contraindications

-       Hypersensitivity to the active substance or to other pyrazolones or pyrazolidines (this includes patients who have reacted with agranulocytosis, for example, after administration of these substances) or to any of the excipients listed in section 6.1.
-       Patients with known analgesic asthma syndrome or known urticaria/angio-oedema type intolerance of analgesics, i.e., patients who react with bronchospasm or other anaphylactoid reactions (e.g., urticaria, rhinitis, angio-oedema) to salicylates, paracetamol or other non- narcotic analgesics such as diclofenac, ibuprofen, indometacin or naproxen.
-       Disturbances of bone marrow function (e.g. after treatment with cytostatics) or disorders of the haematopoietic system.
-       Acute intermittent hepatic porphyria (risk of triggering a porphyria attack).
-       Existing hypotension and unstable circulatory situation.
-       Newborn babies and infants under 3 months of age or weighing less than 5 kg, as no scientific data are available on the safety of its use.
-       Infants (aged 3 months to 1 year) with regard to intravenous injection.