Posology : מינונים

4.2 Posology and method of administration

Treatment of anxiety
The usual anxiolytic dose for adults is 20 – 30 mg daily in divided doses or as a single dose given at night. Doses up to 60 mg daily have been used in the treatment of adult in-patients with severe anxiety.
The lowest dose that can control symptoms should be used. After improvement of the symptoms, the dose may be reduced.
It should not be used for longer than 4 weeks. Long term chronic use as an anxiolytic is not recommended. In certain cases, extension beyond the maximum treatment period may be necessary; treatment must not be extended without re- evaluation of the patient's status using special expertise. It is strongly recommended that prolonged periods of uninterrupted treatment be avoided, since they may lead to dependence. Treatment should always be withdrawn gradually. Patients who have taken Frisium for a long time may require a longer period during which doses are reduced.

Timing of doses:
If the dose is to be spread throughout the day, it is recommended that the larger portion be taken in the evening.


Elderly:
Increased responsiveness and higher susceptibility to adverse effects may be present in elderly patients and require low initial doses and gradual dose increments under careful observation.


Doses of 10 – 20 mg daily in anxiety may be used in the elderly, who are more sensitive to the effects of psychoactive agents.


Patients with renal or hepatic impairment:
Increased responsiveness and higher susceptibility to adverse effects may be present in these patients and require low initial doses and gradual dose increments under careful observation (see Section 4.4).


Tablets can be administered whole, or crushed and mixed in apple sauce (see section 5.2).
The 10 mg tablets can be divided into equal halves of 5 mg.
Clobazam can be given with or without food.


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