Interactions : אינטראקציות

4.5   Interaction with other medicinal products and other forms of interaction
Polio Sabin One and Three (oral) can be administered at the same time as a Haemophilus influenza type b vaccine, a hepatitis B vaccine, a diphtheria, pertussis and/or tetanus vaccine, an inactivated polio vaccine (IPV), a measles, mumps and rubella vaccine or a BCG vaccine, if the vaccination schedule allows.

Concomitant administration of an oral poliomyelitis vaccine (OPV) and rotavirus vaccine does not affect the immune response to polio antigens but can slightly reduce the immune response to the rotavirus vaccine. A clinical trial involving more than 4,200 subjects who received trivalent OPV at the same time as the GlaxoSmithKline Biologicals' rotavirus vaccine (Rotarix) showed that clinical protection against severe rotavirus gastroenteritis was maintained.

If Polio Sabin One and Three (oral) cannot be given at the same time as other live attenuated vaccines, an interval of at least one month should be left between both vaccinations.

Immunosuppressive treatments can reduce the immune response to the vaccine, favour the multiplication of the vaccinal virus and can increase the length of time that the vaccinal virus is excreted in the stools.