Posology : מינונים

4.2    Posology and method of administration

Posology

Adults and adolescents aged 14 years and over
The recommended dose is 1.8 mg administered into one nostril (one nasal spray).

In some cases, further doses may be necessary. The appropriate maximum dose of Nyxoid is situation specific. If the patient does not respond, the second dose should be administered after 2-3 minutes. If the patient responds to the first administration but then relapses again into respiratory depression, the second dose should be administered immediately. Further doses (if available) should be administered in alternate nostrils and the patient should be monitored whilst awaiting arrival of the emergency services. Emergency services may administer further doses according to local guidelines.
Paediatric population

The safety and efficacy of Nyxoid in children below 14 years has not been established. No data are available.

Method of administration

Nasal use.
Nyxoid should be administered as soon as possible to avoid damage to the central nervous system or death.

Nyxoid contains only one dose and therefore it must not be primed or tested prior to administration.

Detailed instructions on how to use Nyxoid are provided in the Package Leaflet and a Quick Start Guide is printed on the back of each blister. In addition, training is provided via a Patient Information Card.