Posology : מינונים

2. DOSAGE AND ADMINISTRATION

2.1 Dosage in Obstructive Sleep Apnea (OSA) and Narcolepsy
The recommended dosage of NUVIGIL for patients with OSA or narcolepsy is 150 mg to 250 mg taken orally once a day as a single dose in the morning.

In patients with OSA, doses up to 250 mg/day, given as a single dose, have been well tolerated, but there is no consistent evidence that these doses confer additional benefit beyond that of the 150 mg/day dose [see Clinical Pharmacology (12.3) and Clinical Studies (14.1, 14.2)].

2.2 Dosage in Shift Work Disorder (SWD)

The recommended dosage of NUVIGIL for patients with SWD is 150 mg taken orally once a day as a single dose approximately 1 hour prior to the start of their work shift.

2.3 Dosage Modification in Patients with Severe Hepatic Impairment

In patients with severe hepatic impairment, the dosage of NUVIGIL should be reduced [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)].

2.4 Use in Geriatric Patients
Consideration should be given to the use of lower doses and close monitoring in geriatric patients [see Use in Specific Populations (8.5)].

3. DOSAGE FORMS AND STRENGTHS
• 50 mg – round, white to off-white tablet with     on one side and "205" on the other • 150 mg – oval, white to off-white tablet with     on one side and "215" on the other • 250 mg – oval, white to off-white tablet with     on one side and "225" on the other