Posology : מינונים

4.2 POSOLOGY AND METHOD OF ADMINISTRATION
The anesthetic nitrogen protoxide induces irreversible oxidation of reduced cobalamin and may Parenteral drug products should be inspected visually for particulate matter and discoloration prior     cause megaloblastic hematopoiesis and concomitant neurological disorders.
to administration, whenever solution and container permit.
Vitamine B12 Sterop 1mg/ml may be given by subcutaneous or intramuscular injection. Do not               4.6 FERTILITY, PREGNANCY AND LACTATION use intravenously.                                                                                       Fertility Pernicious Anemia, Vitamin B12 Deficiency States and Macrocytic Anemias                                  There are no data generated by animal studies concerning the effects of cyanocobalamin on fertility The usual initial dose is 250-1000 micrograms on alternate days for 1-2 weeks, followed by 250           or reproductive performance (see section 5.3).
micrograms weekly until the blood count is normal. Thereafter, the maintenance dose is 1000              Pregnancy micrograms monthly. If there are neurological complications, the initial dose of 1000 micrograms is      There are no or limited amount of data from the use of cyanocobalamin in pregnant women.
recommended on alternate days while improvement is occurring.                                            However, vitamin B12 needs are higher during pregnancy.
Maintenance                                                                                              Studies in animals have shown teratogen effects after a daily exposition during organogenese (see 1000 micrograms monthly.                                                                                 section 5.3).
Cyanocobalamin crosses the placental barrier. This medicine will be used during pregnancy but only Schilling test                                                                                           when the potential benefits of treatment outweigh the risks for the fetus.
The flushing dose is 1000 micrograms.
Breastfeeding