Posology : מינונים

4.2 Posology and method of administration

Epiduo Forte 0.3%/2.5% gel should be applied once a day in the evening to the entire acne affected areas of the face and the trunk on a clean and dry skin.

The duration of treatment should be determined by the doctor based on the overall clinical condition and on the therapeutic response to the treatment. Early signs of clinical improvement usually appear after 1 to 4 weeks of treatment. If no improvement is observed after 4-8 weeks of treatment, the benefit of continued treatment should be reconsidered.

A lower strength of Epiduo is available (Epiduo 0.1%/2.5% gel) and this concentration should be considered in patients with moderate acne vulgaris (see section 5.1).

When the entire face is involved with numerous papulopustules, an increased clinical benefit was observed in the subjects treated with Epiduo Forte 0.3%/2.5% gel compared with the reference therapy (Epiduo 0.1%/2.5% gel).
Doctors may choose between the two concentrations based on the presenting patient's clinical condition and severity 

Special populations
Elderly

The safety and efficacy of Epiduo Forte 0.3%/2.5% gel in geriatric patients aged 65 years and above have not been established.

Renal and hepatic impairment
Epiduo Forte 0.3%/2.5% gel has not been studied in patients with renal and hepatic impairment.

Paediatric population
The safety and efficacy of Epiduo Forte 0.3%/2.5% gel have not been studied in children below 12 years of age.
Method of administration
Cutaneous use only.

Apply a thin layer of Epiduo Forte 0.3%/2.5% gel to affected areas of the face and/or trunk once daily after washing.
Use a pea-sized amount for each area of the face (e.g. forehead, chin, each cheek), avoiding the eyes and lips (see section 4.4).

Patients should be instructed to wash their hands after applying the medicinal product.

Cosmetics may be applied after the medicinal product has dried.
If irritation occurs, the patient should be directed to apply non-comedogenic moisturisers as needed, to use the medication less frequently (e.g. every other day), to suspend use temporarily, or to discontinue use altogether