Adverse reactions : תופעות לוואי

4.8 Undesirable effects
The frequency of undesirable effects is not known.
Immune system disorder:
Hypersensitivity reactions.

Excessive administration of magnesium leads to the development of symptoms of hypermagnesaemia which may include:

Metabolism and nutrition disorders
Electrolyte/fluid abnormalities (hypophosphataemia, hypertonic dehydration) There have been isolated reports of maternal and fetal hypocalcaemia with high doses of magnesium sulfate.

Nervous system disorders
Respiratory depression
Nausea, vomiting, drowsiness and confusion
Coma
Slurred speech, double vision
Loss of tendon reflexes due to neuromuscular blockade

Cardiac disorders
Cardiac arrhythmias, cardiac arrest
ECG abnormal (prolonged PR, QRS and QT intervals), bradycardia
Vascular disorders
Flushing of the skin and hypotension due to peripheral vasodilatation 
Musculoskeletal and connective tissue disorders
Muscle weakness

General disorders and administration site conditions
Thirst
Especially in patients with impaired renal function, there may be sufficient accumulation of magnesium sulfate to produce toxic effects.

Injection/infusion-related
Too rapid administration: Vasodilatation, reduced blood pressure
Local: may be irritant to veins; extravasation may cause tissue damage 
Intramuscular: pain, redness, swelling or warmth at the injection site, drainage at the injection site, prolonged bleeding, cellulitis, sterile abscess, signs of an allergic reaction, such as difficulty breathing or facial swelling, injury to nearby structures (blood vessels, bones, or nerves), inadvertent intravascular or intra-ostial injection, tissue necrosis, poor absorption due to high injectate volume.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product.
Any suspected adverse events should be reported to the Ministry of Health according to the National Regulation by using an online form: https://sideeffects.health.gov.il