Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
Muscle relaxants
The action of non-depolarising muscle relaxants such as tubocurarine is potentiated and prolonged by parenteral magnesium salts.

Calcium channel blockers or diuretics
There is a risk of cardiopulmonary events when intravenous magnesium sulfate is used concomitantly with calcium channel blockers or diuretics (such as thiazides, nifedipine, and furosemide). Profound hypotension has been reported with nifedipine.

Calcium salts
Calcium salts may reduce the efficacy of magnesium.

Digitalis glycosides
Magnesium salts should also be administered with caution to those patients receiving digitalis glycosides.
Neuromuscular blocking agents
Parenteral administration of magnesium salts may enhance the effects of neuromuscular blocking agents. The neuromuscular blocking effects of parenteral magnesium and aminoglycoside antibacterials may be additive.

CNS depressants
When barbiturates, narcotics or other hypnotics (or systemic anesthetics) are to be given in conjunction with magnesium, their dosage should be adjusted with caution because of additive depressant effects of magnesium and the risk of respiratory depression.