Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
Since dopamine is metabolized by monoamine oxidase (MAO), the inhibition of this enzyme for administration of MAO inhibitors prolongs and enhances the effect of dopamine. Dopamine should be used with extreme caution in patients inhaling cyclopropane or hydrocarbons derived from halogenated anesthetics due to the risk of arrhythmias.
Alpha and Beta Blockers: The cardiac effects of dopamine are antagonized by β-adrenergic blocking agents such as propanolol and metoprolol, while secondary peripheral vasoconstriction at high doses of dopamine is antagonized by α-adrenergic blocking agents. The renal and mesenteric vasodilatation is not antagonized by either α- or β-adrenergic blockers, however, in animals, it is antagonized by haloperidol and other butyrophenones, phenothiazines and opioids.
Phenytoin: Intravenous phenytoin administration in patients treated with dopamine has caused hypotension and bradycardia; some clinicians recommend using phenytoin, if clearly needed, with caution in patients receiving dopamine.
Dopamine may increase the effect of diuretics.
Ergot alkaloids must be avoided, due to the risk of excessive vasoconstriction. Tricyclic antidepressants and guanethidine may potentiate dopamine pressure response.